SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-74173B

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP2-03063

Alexa Fluor 350

NBP2-74173AF350

Alexa Fluor 405

NBP2-74173AF405

Alexa Fluor 488

NBP2-74173AF488

Alexa Fluor 532

NBP2-74173AF532

Alexa Fluor 594

NBP2-74173AF594

Alexa Fluor 647

NBP2-74173AF647

Alexa Fluor 700

NBP2-74173AF700

Alexa Fluor 750

NBP2-74173AF750

Allophycocyanin

NBP2-74173APC

CoraFluor 1

NBP2-74173CL1

DyLight 350

NBP2-74173UV

DyLight 405

NBP2-74173V

DyLight 488

NBP2-74173G

DyLight 550

NBP2-74173R

DyLight 594

NBP2-74173DL594

DyLight 650

NBP2-74173C

DyLight 680

NBP2-74173FR

DyLight 755

NBP2-74173IR

FITC

NBP2-74173F

HRP

NBP2-74173H

Janelia Fluor 525

NBP2-74173JF525

Janelia Fluor 549

NBP2-74173JF549

Janelia Fluor 646

NBP2-74173JF646

Janelia Fluor 669

NBP2-74173JF669

mFluor Violet 450 SE

NBP2-74173MFV450

mFluor Violet 500 SE

NBP2-74173MFV500

mFluor Violet 610 SE

NBP2-74173MFV610

PE

NBP2-74173PE

PerCP

NBP2-74173PCP

Forumulation

Catalog #

Azide and BSA Free

NBP2-74173

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine

Applications

Flow Cytometry, Western Blot

Label

Biotin

Antibody Source

Monoclonal Mouse IgG_2A Clone # OTI3F2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SHP-2 Antibodies »

Product Specifications

Immunogen

Full length recombinant protein of human SHP-2/PTPN11 (NP_002825) produced in HEK293T cells.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Applications for SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHP-2

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Long Name

Src Homology Region 2 Domain Phosphatase 2

Alternate Names

PTP1D, PTP2C, PTPN11, SH-PTP2, SHP2

Gene Symbol

PTPN11

Additional SHP-2 Products

Product Documents for SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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