SIRP alpha/CD172a Antibody (S08-1G4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14877

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-14877-100ul
NBP3-14877-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S08-1G4

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SIRP alpha/CD172a Antibodies »

Product Specifications

Immunogen

Recombinant protein of human SIRP alpha/CD172a (Uniprot#: P78324)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

85 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SIRP alpha/CD172a Antibody (S08-1G4)

Western Blot: SIRP alpha/CD172a Antibody (S08-1G4) [NBP3-14877]

Western Blot: SIRP alpha/CD172a Antibody (S08-1G4) [NBP3-14877]

Western Blot: SIRP alpha/CD172a Antibody (S08-1G4) [NBP3-14877] - Western blot detection of SIRP alpha/CD172a in A549, MCF-7, 293T cell lysates using SIRP alpha/CD172a Rabbit mAb (1:1000 diluted). Predicted band size: 55kDa. Observed band size: 85kDa.
SIRP alpha/CD172a Antibody (S08-1G4)

Immunocytochemistry/Immunofluorescence: SIRP alpha/CD172a Antibody (S08-1G4) [NBP3-14877] -

Immunocytochemistry/Immunofluorescence: SIRP alpha/CD172a Antibody (S08-1G4) [NBP3-14877] - Immunocytochemistry of SIRP alpha/CD172a (green) in hela using NBP3-14877 at dilution 1/50, and DAPI (blue)

Applications for SIRP alpha/CD172a Antibody (S08-1G4)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1/50

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SIRP alpha/CD172a

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6) and p84 (7). SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2 (1,2,5,8). SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,8).

Long Name

Signal-regulatory Protein alpha

Alternate Names

BIT, CD172a, MFR, MYD-1, SHPS1, SIRPA

Gene Symbol

SIRPA

Additional SIRP alpha/CD172a Products

Product Documents for SIRP alpha/CD172a Antibody (S08-1G4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SIRP alpha/CD172a Antibody (S08-1G4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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