Synaptophysin Antibody (SYP/7976R) [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20998H

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

HRP

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # SYP/7976R

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Synaptophysin Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa 274-313) of human Synaptophysin protein (exact sequence is proprietary)

Localization

Cytoplasm.

Specificity

This recombinant rabbit monoclonal antibody recognizes a protein of 38kDa that is identified as synaptophysin It is an N-glycosylated integral membrane protein found in neurons and endocrine cells Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for Synaptophysin Antibody (SYP/7976R) [HRP]

Application
Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Synaptophysin

Synaptophysin (Syp I), also called the major synaptic vesicle protein p38, is an integral membrane glycoprotein found in the synaptic vesicles of brain, neuron and neuroendocrine cells. Synaptophysin is one of the most abundant membrane proteins, comprising approximately 7% of the total protein in small synaptic vesicles. In mature nerve terminals it forms a complex with the vesicular membrane protein synaptobrevin, which appears to modulate synaptobrevin's interaction with the plasma membrane-associated proteins syntaxin and SNAP25 to form the SNARE complex as a prerequisite for membrane fusion. Synaptophysin may also be used as a neuroendocrine tumor marker in both neuroscience and cancer research.

Alternate Names

SYP

Gene Symbol

SYP

Additional Synaptophysin Products

Product Documents for Synaptophysin Antibody (SYP/7976R) [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Synaptophysin Antibody (SYP/7976R) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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