TCF7L2 Antibody (CL11547)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21197

Novus Biologicals, part of Bio-Techne
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NBP3-21197-100ul
NBP3-21197-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL11547

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TCF7L2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a Synthetic Peptide of Q9NQB0. Actual immunogen sequence is proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for TCF7L2 Antibody (CL11547)

Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-21197] -

Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-21197] -

Staining of human pancreas shows no nuclear positivity in exocrine glandular cells and islets of Langhernas.
Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-21197] -

Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-21197] -

Staining of mouse thalamus shows strong nuclear positivity in neuronal cells.
Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-21197] -

Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-21197] -

Staining of human rectum shows moderate nuclear positivity in glandular cells.
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Applications for TCF7L2 Antibody (CL11547)

Application
Recommended Usage

Immunohistochemistry

1:200- 1:500

Immunohistochemistry-Paraffin

1:200- 1:500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TCF7L2

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both 946;-cell survival and function (4). Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression (3), and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine (1, 2).

Alternate Names

HMG box transcription factor 4, hTCF-4, T-cell factor 4, T-cell factor-4 variant A, T-cell factor-4 variant B, T-cell factor-4 variant C, T-cell factor-4 variant D, T-cell factor-4 variant E, T-cell factor-4 variant H, T-cell factor-4 variant I, T-cell factor-4 variant J, T-cell factor-4 variant K, T-cell factor-4 variant L, T-cell factor-4 variant M, T-cell factor-4 variant X2, T-cell-specific transcription factor 4, TCF-4T-cell factor-4 variant F, TCF4T-cell factor-4 variant G, transcription factor 7-like 2, transcription factor 7-like 2 (T-cell specific, HMG-box)

Gene Symbol

TCF7L2

Additional TCF7L2 Products

Product Documents for TCF7L2 Antibody (CL11547)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TCF7L2 Antibody (CL11547)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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