TCF7L2 Antibody (CL11547) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44344

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP3-44344
Print Quote
Bulk Order
Forumulation
Catalog #
BSA Free
NBP3-21197
View Product
100% Guarantee

Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL11547

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all TCF7L2 Antibodies »

Product Specifications

Immunogen

This antibody was generated using a synthetic peptide of Q9NQB0, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for TCF7L2 Antibody (CL11547) - Azide and BSA Free

TCF7L2 Antibody (CL11547) - Azide and BSA Free Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-44344]

Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-44344]

Staining of human pancreas shows no nuclear positivity in exocrine glandular cells and islets of Langhorne's.
TCF7L2 Antibody (CL11547) - Azide and BSA Free Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-44344]

Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-44344]

Staining of human lymph node shows very weak nuclear positivity in non-germinal center cells.
TCF7L2 Antibody (CL11547) - Azide and BSA Free Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-44344]

Immunohistochemistry-Paraffin: TCF7L2 Antibody [NBP3-44344]

Staining of human rectum shows moderate nuclear positivity in glandular cells.
View 2 more images

Applications for TCF7L2 Antibody (CL11547) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200- 1:500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Formulation

Lyophilized in 5% Trehalose.

Format

Azide and BSA Free

Preservative

0.02% Sodium Azide

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TCF7L2

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both 946;-cell survival and function (4). Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression (3), and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine (1, 2).

Alternate Names

HMG box transcription factor 4, hTCF-4, T-cell factor 4, T-cell factor-4 variant A, T-cell factor-4 variant B, T-cell factor-4 variant C, T-cell factor-4 variant D, T-cell factor-4 variant E, T-cell factor-4 variant H, T-cell factor-4 variant I, T-cell factor-4 variant J, T-cell factor-4 variant K, T-cell factor-4 variant L, T-cell factor-4 variant M, T-cell factor-4 variant X2, T-cell-specific transcription factor 4, TCF-4T-cell factor-4 variant F, TCF4T-cell factor-4 variant G, transcription factor 7-like 2, transcription factor 7-like 2 (T-cell specific, HMG-box)

Gene Symbol

TCF7L2

Additional TCF7L2 Products

Product Documents for TCF7L2 Antibody (CL11547) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TCF7L2 Antibody (CL11547) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.