TIMP-2 Antibody (MM0035-2C13) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB110-61001

Novus Biologicals, part of Bio-Techne
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NB110-61001
NB110-61001-0.025mg
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # MM0035-2C13

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all TIMP-2 Antibodies »

Product Specifications

Immunogen

Human recombinant TIMP-2

Specificity

No cross-reactivity to human TIMP-1 is noted.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for TIMP-2 Antibody (MM0035-2C13) - Azide and BSA Free

Immunohistochemistry-Paraffin: TIMP-2 Antibody (MM0035-2C13) - Azide and BSA Free [NB110-61001]

Immunohistochemistry-Paraffin: TIMP-2 Antibody (MM0035-2C13) - Azide and BSA Free [NB110-61001]

Immunohistochemistry-Paraffin: TIMP2 Antibody (MM0035-2C13) [NB110-61001] - Formalin fixed and paraffin embedded normal human placenta tissue is subjected to mouse anti human TIMP-2

Applications for TIMP-2 Antibody (MM0035-2C13) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:100-1:200

Western Blot

1:100-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Reconstitution

Reconstitute with sterilized PBS to a final concentration of 0.2 mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TIMP-2

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis. The activation and activity of MMPs are regulated by a family of endogenous inhibitors, tissue inhibitors of metalloproteinase (TIMP). TIMP2 (also called CSC-21K) is a 21 kDa glycoprotein that is expressed by a variety of cell types. It forms a non covalent, stoichiometric complex with both latent and active MMPs. TIMP2 shows a preference for MMP2. TIMPs are capable of altering the metastatic potential of cancer cells and have been shown to inhibit invasion and metastasis in animal models. TIMP2 is constitutively produced in low (pg/ml) levels by most cell types in tissue culture. The low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.

Long Name

Tissue Inhibitors of Metalloproteinases 2

Alternate Names

TIMP2

Entrez Gene IDs

7077 (Human)

Gene Symbol

TIMP2

UniProt

P16035

Additional TIMP-2 Products

Product Documents for TIMP-2 Antibody (MM0035-2C13) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TIMP-2 Antibody (MM0035-2C13) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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