Key Product Details

Species Reactivity

Human

Applications

Flow (Cell Surface), Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 3C10C5

Concentration

1.0 mg/ml

View all TLR10 Antibodies »

Product Specifications

Immunogen

A partial recombinant protein containing amino acids 20-474 (extracellular domain) of human TLR10.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for TLR10 Antibody (3C10C5)

Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343]

Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343]

Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343] - Analysis using the Alexa Fluor (R) 647 conjugate of NBP2-27214. Detection of TLR10 on human PBMC using 10 ul (1 ug) of TLR10 antibody and 1 ug of CD19 antibody. Image using the Azide Free format of this antibody.
Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343]

Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343]

Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343] - Analysis using the PE conjugate of NBP2-27214. Staining of Human PBMC were probed using 10 ul (1 ug) of TLR10 antibody and 1 ug of CD19 antibody.

Applications for TLR10 Antibody (3C10C5)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TLR10

Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms (reviewed in 1). TLRs are primary transmembrane proteins of immune cells; they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kapppa-B and JNK pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes (2). TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.

Long Name

Toll-like Receptor 10

Alternate Names

CD290

Gene Symbol

TLR10

UniProt

Q9BXR5

Additional TLR10 Products

Product Documents for TLR10 Antibody (3C10C5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TLR10 Antibody (3C10C5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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