Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 3C10C5

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TLR10 Antibodies »

Product Specifications

Immunogen

A partial recombinant protein containing amino acids 20-474 (extracellular domain) of human TLR10.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for TLR10 Antibody (3C10C5) [PE]

Flow Cytometry: TLR10 Antibody (3C10C5) [PE] [NBP2-27244] - Cell surface analysis using PE-conjugated TLR10 antibody. Human PBMC were probed using 10 ul (1 ug) of TLR10 antibody and 1 ug of CD19 antibody this antibody . This antibody was used for this test.

Applications for TLR10 Antibody (3C10C5) [PE]

Application
Recommended Usage

Flow Cytometry

1ul/1 million cells
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TLR10

Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms (reviewed in 1). TLRs are primary transmembrane proteins of immune cells; they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kapppa-B and JNk pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes (2). TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.

Long Name

Toll-like Receptor 10

Alternate Names

CD290

Gene Symbol

TLR10

Additional TLR10 Products

Product Documents for TLR10 Antibody (3C10C5) [PE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TLR10 Antibody (3C10C5) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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