ZMPSTE24 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2388

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Mouse

Predicted:

Mouse (96%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all ZMPSTE24 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to a C-terminal portion of the human ZMPSTE24 protein sequence (between residues 400-475). [Swiss-Prot# O75844]

Localization

Integral membrane, primarily ER

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

54 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ZMPSTE24 Antibody

Western Blot: ZMPSTE24 Antibody [NB100-2388]

Western Blot: ZMPSTE24 Antibody [NB100-2388]

Western Blot: ZMPSTE24 Antibody [NB100-2388] - Detection of ZMPSTE24 in human testis.

Applications for ZMPSTE24 Antibody

Application
Recommended Usage

Western Blot

2 ug/ml
Application Notes
This ZMPSTE24 antibody is useful for Western Blot, where a band is seen at ~54 kDa representing ZMPSTE24 protein.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ZMPSTE24

ZMPSTE24 (zinc metalloproteinase Ste24 homolog) is a zinc metalloprotease that catalyzes the removal of C-terminal three residues of farnesylated proteins and is essential for maturation of lamin A (a nuclear scaffold protein). ZMPSTE24 belongs to peptidase M48A family and is a membrane-associated enzyme which contains 7-transmembrane segments localized to ER membrane as well as inner nuclear membrane. ZMPSTE24 contains a consensus zinc metalloprotease motif, consisting of a HEXXH catalytic site, located in a loop predicted to reside in the cytosol/nucleoplasm and farnesylated substrates such as prelamin A are accessible to the HEXXH domain for proteolytic cleavage. Lamin A, together with lamin C and B-type lamins, form the meshwork that underlies the nuclear envelope, and provide structure/shape to the nucleus along with playing many critical roles in nuclear function such as binding of heterochromatin, regulation of transcription factors, positioning of nuclear pore complexes and facilitating response to DNA damage. Defects in ZMPSTE24 have been linked to mandibuloacral dysplasia with type B lipodystrophy (MADB) and lethal tight skin contracture syndrome (LTSCS).

Alternate Names

zona pellucida binding protein 2, zona pellucida-binding protein 2, ZPBP-like protein, ZPBPLMGC41930

Gene Symbol

ZMPSTE24

Additional ZMPSTE24 Products

Product Documents for ZMPSTE24 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ZMPSTE24 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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