IHR-Cy3

Name: IHR-Cy3
Brand: Tocris Bioscience
SKU: 5561

Tocris Bioscience, part of Bio-Techne | Catalog # 5561

COA / SDS

Potent fluorescent Smo antagonist

Discontinued Product

5561 has been discontinued. View all Smoothened Receptor Antagonists products.

Key Product Details

Description:	Potent fluorescent Smo antagonist
Chemical Name:	(2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
Purity:	≥95% (HPLC)
Molecular Weight:	1174.64

View Full Technical Details for IHR-Cy3

Technical Data
Citations

Biological Activity for IHR-Cy3

IHR-Cy3 is a potent fluorescent Smo antagonist (IC₅₀ = 100 nM).

Non-fluorescent analog also available.

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer

Technical Data for IHR-Cy3

M. Wt	1174.64
Formula	C₅₈H₆₃Cl₃N₆O₁₀S₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
PubChem ID	122705984
InChi Key	KBLRMHCNXCHIQG-UHFFFAOYSA-N
Smiles	ClC1=CC=C(Cl)C(C(NC2=CC=C(NC(C3=C(Cl)C=CC(NC(CCCCCCNC(CCCCC[N+]4=C(/C=C/C=C5N(CC)C(C=CC(S(=O)([O-])=O)=C6)=C6C/5(C)C)C(C)(C)C7=C4C=CC(S(=O)(O)=O)=C7)=O)=O)=C3)=O)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for IHR-Cy3

References are publications that support the biological activity of the product.

Fan The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 2014 PMID: 25484239