Recombinant Human Tryptase alpha/beta-1 Protein, CF

Tryptases are trypsin-like serine proteases, with beta tryptases as the main isoenzymes expressed in mast cells (1). They are stored in secretory granules of mast cells, where they form active tetramers with heparin proteoglycan. Because of the unique arrangement of the active sites in the tetramer, which are facing a narrow central pore, beta tryptases are resistant to macromolecule protease inhibitors (2). When mast cells are activated, beta tryptases are released along with other proteins in secretory granules, participating in provoking inflammatory conditions (3). beta tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders. According to the protein sequence, this product was previously labeled as human Tryptase beta-2 protein upon release.  This product has since been renamed as Recombinant Human Tryptase alpha/beta-1 to reflect current sequence alignment per sequence revisions and classification adjustments that have occurred in the NCBI databases.