16,16-Dimethyl Prostaglandin E2

Name: 16,16-Dimethyl Prostaglandin E2
Brand: Tocris Bioscience
SKU: 4027

Tocris Bioscience, part of Bio-Techne | Catalog # 4027

Citations (8)

COA / SDS

Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Key Product Details

Description:	Synthetic prostaglandin E₂ (Cat. No. 2296) derivative; regulates HSC development
Chemical Name:	(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity:	≥95% (HPLC)
Molecular Weight:	380.52

View Full Technical Details for 16,16-Dimethyl Prostaglandin E2

Technical Data
Citations

Biological Activity for 16,16-Dimethyl Prostaglandin E2

16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E₂ (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.

Technical Data for 16,16-Dimethyl Prostaglandin E2

M. Wt	380.52
Formula	C₂₂H₃₆O₅
Storage	Store at -80°C
Purity	≥95% (HPLC)
CAS Number	39746-25-3
PubChem ID	5283066
InChi Key	QAOBBBBDJSWHMU-WMBBNPMCSA-N
Smiles	O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 16,16-Dimethyl Prostaglandin E2

Solubility

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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References for 16,16-Dimethyl Prostaglandin E2

References are publications that support the biological activity of the product.

Heffner Prostaglandin E₂ increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther. 2018 PMID: 29102562
Goessling Genetic interaction of PGE₂ and wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009 PMID: 19303855
North Prostaglandin E₂ regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 PMID: 17581586
Lord Prostaglandin E₂: making more of your marrow. Cell Cycle. 2007 PMID: 18075310