3-MATIDA

Name: 3-MATIDA
Brand: Tocris Bioscience
SKU: 2196

Tocris Bioscience, part of Bio-Techne | Catalog # 2196

Citations (3)

COA / SDS

Potent and selective mGlu1 antagonist

Discontinued Product

2196 has been discontinued. View all Group I mGluR Antagonists products.

Key Product Details

Description:	Potent and selective mGlu₁ antagonist
Chemical Name:	α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid
Purity:	≥99% (HPLC)
Molecular Weight:	215.23

View Full Technical Details for 3-MATIDA

Technical Data
Citations

Biological Activity for 3-MATIDA

Potent metabotropic glutamate mGlu₁ receptor antagonist (IC₅₀ = 6.3 μM at rat mGlu_1a). Displays ≥ 40-fold selectivity over other receptors: mGlu₅, mGlu₂, mGlu_4a (IC₅₀ > 300 μM), NMDA and AMPA (IC₅₀ = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.

Technical Data for 3-MATIDA

M. Wt	215.23
Formula	C₈H₉NO₄S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	518357-51-2
PubChem ID	10398360
InChi Key	KOMWRBFEDDEWEP-UHFFFAOYSA-N
Smiles	CC1=C(SC(=C1)C(O)=O)C(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 3-MATIDA

References are publications that support the biological activity of the product.

Cozzi Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neuropharmacology 2002 PMID: 12213266
Constantino Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist. Il Farmaco 2004 PMID: 14871500
Moroni The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology 2002 PMID: 12015200

3-MATIDA

Tocris Bioscience, part of Bio-Techne | Catalog # 2196

Key Product Details

Biological Activity for 3-MATIDA

Technical Data for 3-MATIDA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 3-MATIDA

Product Documents for 3-MATIDA

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected