5,7-Dichlorokynurenic acid

Name: 5,7-Dichlorokynurenic acid
Brand: Tocris Bioscience
SKU: 0286

Tocris Bioscience, part of Bio-Techne | Catalog # 0286

Citations (22)

COA / SDS

Potent NMDA antagonist; acts at glycine site

Key Product Details

Description:	Potent NMDA antagonist; acts at glycine site
Chemical Name:	5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	258.06

View Full Technical Details for 5,7-Dichlorokynurenic acid

Technical Data
Citations

Biological Activity for 5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (K_i = 79 nM vs. [³H]-glycine).

Sodium Salt also available.

Compound Libraries for 5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 5,7-Dichlorokynurenic acid

M. Wt	258.06
Formula	C₁₀H₅Cl₂NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	131123-76-7
PubChem ID	1779
InChi Key	BGKFPRIGXAVYNX-UHFFFAOYSA-N
Smiles	OC(=O)C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5,7-Dichlorokynurenic acid

	Solvent	Max Conc. mM
Solubility
	1eq. NaOH	100
	DMSO	100

Preparing Stock Solutions for 5,7-Dichlorokynurenic acid

The following data is based on the product molecular weight 258.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.88 mL	19.38 mL	38.75 mL
5 mM	0.78 mL	3.88 mL	7.75 mL
10 mM	0.39 mL	1.94 mL	3.88 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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Reconstitution Calculator

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References for 5,7-Dichlorokynurenic acid

References are publications that support the biological activity of the product.

Moore Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I
Baron Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 1990 PMID: 2172769