5-Amino-Thalidomide

Name: 5-Amino-Thalidomide
Brand: Tocris Bioscience
SKU: 7678

Tocris Bioscience, part of Bio-Techne | Catalog # 7678

COA / SDS

Cereblon ligand with amine on C5 for onward chemistry

Key Product Details

Description:	Cereblon ligand with amine on C5 for onward chemistry
Chemical Name:	5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)
Molecular Weight:	273.24

View Full Technical Details for 5-Amino-Thalidomide

Technical Data
Citations

Biological Activity for 5-Amino-Thalidomide

5-Amino-Thalidomide is a functionalized cereblon (CRBN) ligand for PROTAC® research and development; incorporates an E3 ligase ligand with an amine on the C5 position of the phthalimide ring for onward chemistry to generate Protein Degraders with rigid linkers. Degraders with modifications on the C5 position reduce off-target zinc-finger proteins degradation.

Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for 5-Amino-Thalidomide

M. Wt	273.24
Formula	C₁₃H₁₁N₃O₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	191732-76-0
InChi Key	IICWMVJMJVXCLY-UHFFFAOYSA-N
Smiles	O=C1C2=CC=C(N)C=C2C(=O)N1C3C(=O)NC(=O)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 5-Amino-Thalidomide

References are publications that support the biological activity of the product.