5,7-Dichlorokynurenic acid sodium salt

Name: 5,7-Dichlorokynurenic acid sodium salt
Brand: Tocris Bioscience
SKU: 3698

Tocris Bioscience, part of Bio-Techne | Catalog # 3698

Citations (4)

COA / SDS

Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid

Key Product Details

Chemical Name:	5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity:	≥98%
Molecular Weight:	280.04 kDa

View Full Technical Details for 5,7-Dichlorokynurenic acid sodium salt

Technical Data
Citations

Biological Activity for 5,7-Dichlorokynurenic acid sodium salt

5,7-Dichlorokynurenic acid sodium salt is a sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (K_i = 79 nM vs. [³H]-glycine).

Technical Data for 5,7-Dichlorokynurenic acid sodium salt

M. Wt	280.04 kDa
Formula	C₁₀H₄Cl₂NNaO₃
Storage	Desiccate at RT
Purity	≥98%
CAS Number	1184986-70-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5,7-Dichlorokynurenic acid sodium salt

Solubility

Soluble Soluble to 100 mM in 1eq. NaOH

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References for 5,7-Dichlorokynurenic acid sodium salt

References are publications that support the biological activity of the product.

Baron et al. Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol., 1990;38:554 PMID: 2172769
Moore et al. Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I, 1990;