A 71915

Name: A 71915
Brand: Tocris Bioscience
SKU: 6715

Tocris Bioscience, part of Bio-Techne | Catalog # 6715

Citations (2)

COA / SDS

Highly potent and competitive NPRA antagonist

Key Product Details

Description:	Highly potent and competitive NPRA antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1613.95

View Full Technical Details for A 71915

Technical Data
Citations

Biological Activity for A 71915

A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pK_i = 9.18). Reduces brain natriuretic peptide (BNP, Cat. No. 3522)-induced scratching in mice.

Technical Data for A 71915

M. Wt	1613.95
Formula	C₆₉H₁₁₆N₂₆O₁₅S₂
Single Letter Sequence	RCXGGRIDRIXRC (Modifications: X-3 = Cha, X-11= D-Tic, Cys-13 = C-terminal amide, Disulfide bridge: 2-13)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	132956-87-7
PubChem ID	25083020
InChi Key	TZQXLCWSYQJGKV-YGLLJKSHSA-N
Smiles	CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](CSS[C@H](CCCN=C(N)N)[C@H](NC(=O)CNC(=O)[C@H]2CC3=CC=CC=C3CN2C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)CC)C(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 71915

Solubility

Soluble to 1mg/ml in water

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References for A 71915

References are publications that support the biological activity of the product.

Moro Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells. J.Pharmacol.Exp.Ther. 2004 PMID: 14634036
Kiguchi Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. J.Pharmacol.Exp.Ther. 2016 PMID: 26669425
Delporte Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur.J.Pharmacol. 1992 PMID: 1334838