A 987306

Name: A 987306
Brand: Tocris Bioscience
SKU: 3640

Tocris Bioscience, part of Bio-Techne | Catalog # 3640

COA / SDS

Potent and selective H4 antagonist

Discontinued Product

3640 has been discontinued. View all Histamine H4 Receptor Antagonists products.

Key Product Details

Description:	Potent and selective H₄ antagonist
Chemical Name:	(±)-(7aR,11aR)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	327.42

View Full Technical Details for A 987306

Technical Data
Citations

Biological Activity for A 987306

A 987306 is a potent histamine H₄ receptor antagonist (pK_i values are 8.24 and 8.47 in human and rat H₄ receptors respectively). Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H₃, H₁ and H₂ receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED₅₀ = 42 μmol/kg, ip).

Technical Data for A 987306

M. Wt	327.42
Formula	C₁₈H₂₅N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1082954-71-9
PubChem ID	25109291
InChi Key	DJKJVWJQAVGLHJ-YPMHNXCESA-N
Smiles	NC3=NC1=C(C(N4CCNCC4)=N3)CCC2=C1[C@@](CCCC5)([H])[C@@]5([H])O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for A 987306

References are publications that support the biological activity of the product.

Leurs Molecular and biochemical pharmacology of the histamine H₄ receptor. Br.J.Pharmacol. 2009 PMID: 19413568
Liu cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H₄R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. J.Med.Chem. 2008 PMID: 18983139

A 987306

Tocris Bioscience, part of Bio-Techne | Catalog # 3640

Key Product Details

Biological Activity for A 987306

Technical Data for A 987306

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for A 987306

Product Documents for A 987306

COA

Certificate of Analysis

SDS

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