ABT 263

Name: ABT 263
Brand: Tocris Bioscience
SKU: 7680
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 7680

Citations (2)

COA / SDS

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Key Product Details

Description:	High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
Chemical Name:	4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	974.62

View Full Technical Details for ABT 263

Technical Data
Citations

Biological Activity for ABT 263

ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (K_i values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively). ABT 263 induces G₁/G₀ phase arrest, apoptosis and autophagy in cancer cells in vitro (IC₅₀ = 3.4 - 12 μM). In vivo, ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat. No. 7282), Docetaxel (Cat. No. 4056) and Erlotinib (Cat. No. 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat. No. 4499). ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo, and clears senescent cells and rejuvenates aging stem cells. Orally bioavailable.

Technical Data for ABT 263

M. Wt	974.62
Formula	C₄₇H₅₅ClF₃N₅O₆S₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	923564-51-6
PubChem ID	24978538
InChi Key	JLYAXFNOILIKPP-KXQOOQHDSA-N
Smiles	C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABT 263

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	97.46	100

Preparing Stock Solutions for ABT 263

The following data is based on the product molecular weight 974.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.03 mL	5.13 mL	10.26 mL
5 mM	0.21 mL	1.03 mL	2.05 mL
10 mM	0.10 mL	0.51 mL	1.03 mL
50 mM	0.02 mL	0.10 mL	0.21 mL

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References for ABT 263

References are publications that support the biological activity of the product.

Chang Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat.Med. 2016 PMID: 26657143
Lee Virus-induced senescence is a driver and therapeutic target in COVID-19. Nature 2021 PMID: 34517409
Wang JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer. Oncotarget 2017 PMID: 29156797
Tse ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008 PMID: 18451170
Chen The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol.Cancer Ther. 2011 PMID: 21914853