AC 261066

Name: AC 261066
Brand: Tocris Bioscience
SKU: 4046

Tocris Bioscience, part of Bio-Techne | Catalog # 4046

Citations (8)

COA / SDS

RARβ2 agonist

Key Product Details

Chemical Name:	4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid
Purity:	≥98%
Molecular Weight:	353.41 kDa

View Full Technical Details for AC 261066

Technical Data
Citations

Biological Activity for AC 261066

AC 261066 is a potent RARβ2 agonist (pEC₅₀ = 8.1). Selective over RARβ1, RARα and RARγ (pEC₅₀ values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).

Technical Data for AC 261066

M. Wt	353.41 kDa
Formula	C₁₇H₂₀FNO₄S
Storage	Store at RT
Purity	≥98%
CAS Number	870773-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 261066

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for AC 261066

References are publications that support the biological activity of the product.

Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity. Biochem Biophys Res Commun, 2014;454(4):537-542. 2014 PMID: 25450689
M Melis, XH Tang, SE Trasino, VM Patel, DJ Stummer, J Jessurun, LJ Gudas Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease PLoS ONE, 2019;14(1):e0211071. 2019 PMID: 30677086
Lund et al. Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem., 2005;48:7517 PMID: 16302793
Lund et al. Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands. J.Med.Chem., 2009;52:1540 PMID: 19239230