AEE 788

Tocris Bioscience, part of Bio-Techne | Catalog # 5318

(2)

Citations (2)

COA / SDS

Potent EGFR and VEGFR inhibitor

Key Product Details

Chemical Name:	6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥98%

View Full Technical Details for AEE 788

Technical Data
Citations / Reviews (2)

Biological Activity for AEE 788

AEE 788 is a potent EGFR and VEGFR inhibitor (IC₅₀ values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC₅₀ values are 52, 60 and 61 nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro. Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.

Technical Data for AEE 788

Formula	C₂₇H₃₂N₆
Storage	Store at -20°C
Purity	≥98%
CAS Number	497839-62-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AEE 788

Solubility

Soluble Soluble to 100 mM in DMSO

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References for AEE 788

References are publications that support the biological activity of the product.

Traxler et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res., 2004;64:4931 PMID: 15256466
Yokoi et al. Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. Cancer Res., 2005;65:3716 PMID: 15867367

AEE 788

Tocris Bioscience, part of Bio-Techne | Catalog # 5318

Key Product Details

Biological Activity for AEE 788

Technical Data for AEE 788

Solubility for AEE 788

Dilution Calculator

Reconstitution Calculator

References for AEE 788

Product Documents for AEE 788

COA

Certificate of Analysis

SDS

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