AMG 517

Biological Activity for AMG 517

Technical Data for AMG 517

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 517

References for AMG 517

References are publications that support the biological activity of the product.

• Doherty et al. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. J.Med.Chem., 2007;50:3515 PMID: 17585750
• Gavva et al. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J.Pharmacol.Exp.Ther., 2007;323:128 PMID: 17652633
• Wang et al. Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J.Med.Chem., 2007;50:3528 PMID: 17585751