AR-C 69931 tetrasodium salt

Name: AR-C 69931 tetrasodium salt
Brand: Tocris Bioscience
SKU: 5720

Tocris Bioscience, part of Bio-Techne | Catalog # 5720

Citations (66)

COA / SDS

Highly potent P2Y12 antagonist

Key Product Details

Description:	Highly potent P2Y₁₂ antagonist
Alternative Names:	Cangrelor tetrasodium salt
Chemical Name:	N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphate tetrasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	864.29

View Full Technical Details for AR-C 69931 tetrasodium salt

Technical Data
Citations

Biological Activity for AR-C 69931 tetrasodium salt

AR-C 69931 tetrasodium salt is a highly potent P2Y₁₂ antagonist (IC₅₀ = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo. Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo.

Technical Data for AR-C 69931 tetrasodium salt

M. Wt	864.29
Formula	C₁₇H₂₁Cl₂F₃N₅Na₄O₁₂P₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	163706-36-3
PubChem ID	10260031
InChi Key	COWWROCHWNGJHQ-OPKBHZIBSA-J
Smiles	O[C@@H]1[C@H](O)[C@@H](N2C3=NC(SCCC(F)(F)F)=NC(NCCSC)=C3N=C2)O[C@H]1COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AR-C 69931 tetrasodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	86.43	100

Preparing Stock Solutions for AR-C 69931 tetrasodium salt

The following data is based on the product molecular weight 864.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.16 mL	5.79 mL	11.57 mL
5 mM	0.23 mL	1.16 mL	2.31 mL
10 mM	0.12 mL	0.58 mL	1.16 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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References for AR-C 69931 tetrasodium salt

References are publications that support the biological activity of the product.

Ingall Antagonists of the platelet P_2T receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 1999 PMID: 9925726
Srinivasan The P2Y₁₂ antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a G_i-independent increase in cAMP levels. J.Biol.Chem. 2009 PMID: 19346255
Huang Prevention of arterial thrombosis by intravenously administered platelet P_2T receptor antagonist AR-C69931MX in a canine model. J.Pharmacol.Exp.Ther. 2000 PMID: 11046080