AZD 1480

Name: AZD 1480
Brand: Tocris Bioscience
SKU: 5617

Tocris Bioscience, part of Bio-Techne | Catalog # 5617

Citations (4)

COA / SDS

Potent and selective JAK2 inhibitor; antiangiogenic

Key Product Details

Description:	Potent and selective JAK2 inhibitor; antiangiogenic
Chemical Name:	5-Chloro-N²-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N⁴-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine
Purity:	≥98% (HPLC)
Molecular Weight:	348.77

View Full Technical Details for AZD 1480

Technical Data
Citations

Biological Activity for AZD 1480

AZD 1480 is a potent and selective JAK2 inhibitor (IC₅₀ < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.

Compound Libraries for AZD 1480

AZD 1480 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 1480

M. Wt	348.77
Formula	C₁₄H₁₄ClFN₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	935666-88-9
PubChem ID	16659841
InChi Key	PDOQBOJDRPLBQU-QMMMGPOBSA-N
Smiles	C[C@@H](C1=NC=C(F)C=N1)NC2=NC=C(Cl)C(NC3=NNC(C)=C3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 1480

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.88	100
	ethanol	34.88	100

Preparing Stock Solutions for AZD 1480

The following data is based on the product molecular weight 348.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.34 mL	28.67 mL
5 mM	0.57 mL	2.87 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for AZD 1480

References are publications that support the biological activity of the product.

Xin Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 2011 PMID: 21920898
Ioannidis S Discovery of 5-chloro-N²-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N⁴-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J.Med.Chem. 2011 PMID: 21138246