JAK Kinase Inhibitors: Small Molecules and Peptides
15 results for "JAK Kinase Inhibitors Small Molecules and Peptides" in Products
15 results for "JAK Kinase Inhibitors Small Molecules and Peptides" in Products
JAK Kinase Inhibitors: Small Molecules and Peptides
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
| Alternate Names: | Tyrphostin AG 490 |
| Chemical Name: | (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide |
| Purity: | ≥99% (HPLC) |
Potent JAK inhibitor
| Alternate Names: | Tofacitinib citrate |
| Chemical Name: | (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate |
| Purity: | ≥99% (HPLC) |
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
| Alternate Names: | INCB 28050 |
| Chemical Name: | 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Purity: | ≥98% (HPLC) |
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
| Alternate Names: | INCB018424 |
| Chemical Name: | (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
| Purity: | ≥98% (HPLC) |
Potent, selective JAK3 inhibitor
| Chemical Name: | 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride |
| Purity: | ≥99% (HPLC) |
JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
| Alternate Names: | CEP-701 |
| Chemical Name: | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one |
| Purity: | ≥98% (HPLC) |
Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor
| Chemical Name: | (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate |
| Purity: | ≥98% (HPLC) |
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
| Alternate Names: | JAK inhibitor I |
| Chemical Name: | 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of STAT3/JAK2 signaling
| Alternate Names: | Elatericin B,JSI 124 |
| Chemical Name: | (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione |
| Purity: | ≥95% (HPLC) |
Potent and selective JAK2 inhibitor; antiangiogenic
| Chemical Name: | 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine |
| Purity: | ≥98% (HPLC) |
Potent and selective JAK3 inhibitor
| Chemical Name: | 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate |
| Purity: | ≥98% (HPLC) |
Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
| Alternate Names: | NIBR3049 |
| Chemical Name: | 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
JAK2/STAT3 signaling pathway inhibitor
| Chemical Name: | (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester |
| Purity: | ≥99% (HPLC) |
Potent Mnk2 inhibitor
| Chemical Name: | (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide |
| Purity: | ≥96% (HPLC) |
Potent TYK2 inhibitor
| Chemical Name: | 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide |
| Purity: | ≥98% (HPLC) |
