AZD 2098

Name: AZD 2098
Brand: Tocris Bioscience
SKU: 6541

Tocris Bioscience, part of Bio-Techne | Catalog # 6541

COA / SDS

Potent and selective CCR4 antagonist

Key Product Details

Description:	Potent and selective CCR4 antagonist
Chemical Name:	2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	334.18

View Full Technical Details for AZD 2098

Technical Data
Citations

Biological Activity for AZD 2098

AZD 2098 is a potent and selective CCR4 antagonist (pIC₅₀ = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca²⁺ response and Th2 cell CCL17/22 driven chemotaxis in vitro. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.

Compound Libraries for AZD 2098

AZD 2098 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 2098

M. Wt	334.18
Formula	C₁₁H₉Cl₂N₃O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	566203-88-1
PubChem ID	10308720
InChi Key	FLSMVCMSUNISFK-UHFFFAOYSA-N
Smiles	COC1=NC=CN=C1NS(=O)(C2=C(Cl)C(Cl)=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 2098

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.42	100
	ethanol	3.34	10

Preparing Stock Solutions for AZD 2098

The following data is based on the product molecular weight 334.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.99 mL	14.96 mL	29.92 mL
5 mM	0.60 mL	2.99 mL	5.98 mL
10 mM	0.30 mL	1.50 mL	2.99 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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Reconstitution Calculator

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References for AZD 2098

References are publications that support the biological activity of the product.

Kindon Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists. ACS Med.Chem.Lett. 2017 PMID: 28947948
Mullard Cancer charity sees success re-prioritizing industry's shelved compounds. Nat.Rev.Drug Discov. 2014 PMID: 24781536
Toogood Small molecule immuno-oncology therapeutic agents. Bioorg.Med.Chem.Lett. 2017 PMID: 29326017