BAY 678

Name: BAY 678
Brand: Tocris Bioscience
SKU: 5706

Tocris Bioscience, part of Bio-Techne | Catalog # 5706

Citations (1)

COA / SDS

Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor

Key Product Details

Description:	Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor
Chemical Name:	5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	400.35

View Full Technical Details for BAY 678

Technical Data
Citations

Biological Activity for BAY 678

BAY 678 is a potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC₅₀ = 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury model in vivo. Orally bioavailable. Inactive S-enantiomer (Cat.No.6389) also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 678 probe summary on the SGC website.

Technical Data for BAY 678

M. Wt	400.35
Formula	C₂₀H₁₅F₃N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	675103-36-3
PubChem ID	23728722
InChi Key	PGIVGIFOWOVINL-GOSISDBHSA-N
Smiles	CC(C([C@H]1C2=CN=C(C#N)C=C2)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C(N1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 678

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.03	100

Preparing Stock Solutions for BAY 678

The following data is based on the product molecular weight 400.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.98 mL
5 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for BAY 678

References are publications that support the biological activity of the product.

von Nussbaum Freezing the bioactive conformation to boost potency: The identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases. ChemMedChem. 2015 PMID: 26083237