BOP

Tocris Bioscience, part of Bio-Techne | Catalog # 6047

COA / SDS

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Key Product Details

Chemical Name:	N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Purity:	≥98%

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Technical Data
Citations

Biological Activity for BOP

BOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).

Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.

High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.

Technical Data for BOP

Formula	C₂₅H₂₈N₃O₇SNa
Storage	Store at -20°C
Purity	≥98%
CAS Number	1947348-42-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BOP

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for BOP

References are publications that support the biological activity of the product.

Cao et al. Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun., 2016;7:11007 PMID: 26975966
Cao et al. Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem., 2014;12:965 PMID: 24363056
Pepinsky et al. Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1. Biochemistry, 2002;41:7125 PMID: 12033947

BOP

Tocris Bioscience, part of Bio-Techne | Catalog # 6047

Key Product Details

Biological Activity for BOP

Technical Data for BOP

Solubility for BOP

Dilution Calculator

Reconstitution Calculator

References for BOP

Product Documents for BOP

COA

Certificate of Analysis

SDS

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