Carboplatin

Name: Carboplatin
Brand: Tocris Bioscience
SKU: 2626

Tocris Bioscience, part of Bio-Techne | Catalog # 2626

(1)

Citations (23)

COA / SDS

DNA cross-linking antitumor agent

Key Product Details

Chemical Name:	cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Purity:	≥99%
Molecular Weight:	371.25 kDa

View Full Technical Details for Carboplatin

Technical Data
Citations / Reviews (1)

Biological Activity for Carboplatin

Carboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).

Technical Data for Carboplatin

M. Wt	371.25 kDa
Formula	C₆H₁₂N₂O₄Pt
Storage	Store at RT
Purity	≥99%
CAS Number	41575-94-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Carboplatin

Solubility

Soluble Soluble to 25 mM in water

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References for Carboplatin

References are publications that support the biological activity of the product.

K Ishiguro, YL Zhu, ZP Lin, PG Penketh, K Shyam, R Zhu, RP Baumann, AC Sartorelli, TJ Rutherford, ES Ratner Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines J Transl Sci, 2016;2(2):117-124. 2016 PMID: 27076919
Natarajan et al. Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol., 1999;58:1625 PMID: 10535754
Yang et al. Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res., 1995;143:302
Thomas et al. High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisp. but not carbop. ototoxicity. Mol.Pharmacol., 2006;70:23 PMID: 16569706

Product Documents for Carboplatin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Carboplatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov