CGP 54626 hydrochloride

Name: CGP 54626 hydrochloride
Brand: Tocris Bioscience
SKU: 1088

Tocris Bioscience, part of Bio-Techne | Catalog # 1088

Citations (42)

COA / SDS

Potent and selective GABAB antagonist

Key Product Details

Description:	Potent and selective GABA_B antagonist
Chemical Name:	[S-(R,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid
Purity:	≥96% (HPLC)
Molecular Weight:	444.76

View Full Technical Details for CGP 54626 hydrochloride

Technical Data
Citations

Biological Activity for CGP 54626 hydrochloride

CGP 54626 hydrochloride is a potent, selective GABA_B receptor antagonist (IC₅₀ = 4 nM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Compound Libraries for CGP 54626 hydrochloride

CGP 54626 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 54626 hydrochloride

M. Wt	444.76
Formula	C₁₈H₂₈Cl₂NO₃P.HCl
Storage	Store at RT
Purity	≥96% (HPLC)
CAS Number	149184-21-4
PubChem ID	197583
InChi Key	ZQCFHOVIXCJPLE-LINSIKMZSA-N
Smiles	OP(CC1CCCCC1)(C[C@@H](O)CN[C@@H](C)C2=CC(Cl)=C(Cl)C=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 54626 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.24	50
	ethanol	4.45	10 with gentle warming

Preparing Stock Solutions for CGP 54626 hydrochloride

The following data is based on the product molecular weight 444.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.50 mL	22.48 mL	44.97 mL
2.5 mM	0.90 mL	4.50 mL	8.99 mL
5 mM	0.45 mL	2.25 mL	4.50 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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References for CGP 54626 hydrochloride

References are publications that support the biological activity of the product.

Kaupmann GABA_B-receptor subtypes assemble into functional heteromeric complexes. Nature 1998 PMID: 9872317
Froestl Potent, orally active GABA_B receptor antagonists. Pharmacol.Rev.Comm.
Brugger The action of new potent GABA_B receptor antagonists in the hemisected spinal cord preparation of the rat. Eur.J.Pharmacol. 1993 PMID: 8390938