Concanamycin A

Name: Concanamycin A
Brand: Tocris Bioscience
SKU: 2656

Tocris Bioscience, part of Bio-Techne | Catalog # 2656

Citations (23)

COA / SDS

H+-ATPase (vacuolar) inhibitor

Key Product Details

Description:	H⁺-ATPase (vacuolar) inhibitor
Alternative Names:	Folimycin
Chemical Name:	(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
Purity:	≥90% (HPLC)
Molecular Weight:	866.09

View Full Technical Details for Concanamycin A

Technical Data
Citations

Biological Activity for Concanamycin A

Concanamycin A is a specific inhibitor of V-type (vacuolar) H⁺-ATPase that displays > 2000-fold selectivity over other H⁺-ATPases (IC₅₀ values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H⁺-ATPases and porcine P-type Na⁺,K⁺-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

Technical Data for Concanamycin A

M. Wt	866.09
Formula	C₄₆H₇₅NO₁₄
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	80890-47-7
PubChem ID	6438151
InChi Key	DJZCTUVALDDONK-HQMSUKCRSA-N
Smiles	O=C1O[C@@]([C@@H](C)[C@@H](O)[C@H](C)[C@]2(O)O[C@H](/C=C/C)[C@@H](C)[C@H](O[C@]3([H])O[C@H](C)[C@@H](OC(N)=O)[C@H](O)C3)C2)([H])[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Concanamycin A

References are publications that support the biological activity of the product.

Muroi Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function.
Nishihara Specific inhibitors of vacuolar type H⁺-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm.
Hong Nitric oxide production by the vacuolar-type (H⁺)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 2006 PMID: 16895977

Concanamycin A

Tocris Bioscience, part of Bio-Techne | Catalog # 2656

Key Product Details

Biological Activity for Concanamycin A

Technical Data for Concanamycin A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Concanamycin A

Product Documents for Concanamycin A

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected