CP 690550 citrate

Name: CP 690550 citrate
Brand: Tocris Bioscience
SKU: 4556
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4556

(1)

Citations (13)

COA / SDS

Potent JAK inhibitor

Key Product Details

Description:	Potent JAK inhibitor
Alternative Names:	Tofacitinib citrate
Chemical Name:	(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate
Purity:	≥99% (HPLC)
Molecular Weight:	504.49

View Full Technical Details for CP 690550 citrate

Technical Data
Citations / Reviews (1)

Biological Activity for CP 690550 citrate

CP 690550 citrate is a potent JAK inhibitor (IC₅₀ values are 1, 20, and 112 nM for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 690550 citrate

CP 690550 citrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 690550 (Tofacitinib) is reviewed on the chemical probes website.

Technical Data for CP 690550 citrate

M. Wt	504.49
Formula	C₁₆H₂₀N₆O.C₆H₈O₇
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	540737-29-9
PubChem ID	10174505
InChi Key	SYIKUFDOYJFGBQ-YLAFAASESA-N
Smiles	C[C@H]1[C@@H](N(C2=NC=NC3=C2C=CN3)C)CN(C(CC#N)=O)CC1.OC(CC(O)=O)(C(O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 690550 citrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.45	100

Preparing Stock Solutions for CP 690550 citrate

The following data is based on the product molecular weight 504.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.91 mL	19.82 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for CP 690550 citrate

References are publications that support the biological activity of the product.

Flanagan Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J.Med.Chem. 2010 PMID: 21105711
Dowty Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J.Pharmacol.Exp.Ther. 2013 PMID: 24218541
Jiang Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J.Med.Chem. 2008 PMID: 19053756