CP 690550 citrate

Biological Activity for CP 690550 citrate

Technical Data for CP 690550 citrate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 690550 citrate

References for CP 690550 citrate

References are publications that support the biological activity of the product.

• Dowty, Martin E, Jesson, Michael, Ghosh, Sarbani, Lee, Jamie, Meyer, Debra M, Krishnaswami, Sriram, Kishore, Nandini Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J Pharmacol Exp Ther, 2013-11-11;348(1):165-73. 2013-11-11 PMID: 24218541
• Zhu Y, Brown J, Sag D, Zhang L, Suttles J Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages. J Immunol, 2015;194(2):584-94. 2015 PMID: 25512602
• Jiang et al. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J.Med.Chem., 2008;51:8012 PMID: 19053756
• Flanagan et al. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J.Med.Chem., 2010;53:8468 PMID: 21105711