Cyclosporin A

Name: Cyclosporin A
Brand: Tocris Bioscience
SKU: 1101

Tocris Bioscience, part of Bio-Techne | Catalog # 1101

(1)

Citations (102)

COA / SDS

Calcineurin inhibitor

Key Product Details

Purity:	≥99%
Molecular Weight:	1202.63 kDa

View Full Technical Details for Cyclosporin A

Technical Data
Citations / Reviews (1)

Biological Activity for Cyclosporin A

Cyclosporin A is an immunosuppressant; simultaneously binds calcineurin and cyclophilin and inhibits phosphatase activity of calcineurin (IC₅₀ = 5 nM). Additionally inhibits formation and opening of the mitochondrial permeability transition pore (MPTP). Also inhibits coronavirus replication in vitro. Enhances lentirival transduction of bone marrow-derived CD34⁺ cells and is additive with Prostaglandin E₂ (Cat. No. 2296).

Technical Data for Cyclosporin A

M. Wt	1202.63 kDa
Formula	C₆₂H₁₁₁N₁₁O₁₂
Storage	Store at -20°C
Purity	≥99%
CAS Number	59865-13-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclosporin A

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for Cyclosporin A

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Y Yue, NR Nabar, CS Shi, O Kamenyeva, X Xiao, IY Hwang, M Wang, JH Kehrl SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death Cell Death Dis, 2018;9(9):904. 2018 PMID: 30185776
Jean-Quartier C, Bondarenko AI, Alam MR Studying mitochondrial Ca(2+) uptake - a revisit. Mol. Cell. Endocrinol., 2012;353(1):114-27. 2012 PMID: 22100614
N Gourdin, M Bossennec, C Rodriguez, S Vigano, C Machon, C Jandus, D Bauché, J Faget, I Durand, N Chopin, O Tredan, JC Marie, B Dubois, J Guitton, P Romero, C Caux, C Ménétrier- Autocrine Adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints Cancer Res., 2018;0(0):. 2018 PMID: 29559470
Moguche A, Shafiani S, Clemons C, Larson R, Dinh C, Higdon L, Cambier C, Sissons J, Gallegos A, Fink P, Urdahl K ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. J Exp Med, 2015;212(5):715-28. 2015 PMID: 25918344
SG Cho APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway Oncol Lett, 2017;14(4):4845-4852. 2017 PMID: 29085490
Miyamoto T, Kim D, Knox J, Johnson E, Mucke L Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-beta-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem, 2016;291(4):1719-34. 2016 PMID: 26589795
Yan et al. Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. BiochemsBiophys.Res.Commun., 2009;379:115 PMID: 19094963
Brookemeier and Pfeiffer Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry, 1995;34:16440 PMID: 8845372
Fruman et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc.Natl.Acad.Sci.U.S.A., 1992;89:3686 PMID: 1373887
Nakata et al. Evidence that cyclosporin A and dexameth. inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells. Br.J.Pharmacol., 1998;124:1425 PMID: 9723954
Petrillo et al. Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant Ex Vivo gene therapy settings. Hum.Gene.Ther., 2019; PMID: 31037976
de Wilde et al. Cyclosporin A inhibits the replication of diverse coronaviruses. J.Gen.Virol., 2011;92:2542 PMID: 21752960
de Wilde et al. MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment. J.Gen.Virol., 2013;94:1749 PMID: 23620378
Carbajo-Lozoya et al. Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir. Virus Res., 2014;184:44 PMID: 24566223