D-CPP-ene

Name: D-CPP-ene
Brand: Tocris Bioscience
SKU: 1265

Tocris Bioscience, part of Bio-Techne | Catalog # 1265

Citations (11)

COA / SDS

Potent competitive NMDA antagonist

Key Product Details

Description:	Potent competitive NMDA antagonist
Alternative Names:	Midafotel,SDZ EAA 494
Chemical Name:	D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
Molecular Weight:	250.19

View Full Technical Details for D-CPP-ene

Technical Data
Citations

Biological Activity for D-CPP-ene

D-CPP-ene is a potent and competitive NMDA antagonist (K_i = 40 nM). Centrally active following systemic administration.

Technical Data for D-CPP-ene

M. Wt	250.19
Formula	C₈H₁₅N₂O₅P
Storage	Desiccate at RT
CAS Number	117414-74-1
PubChem ID	6435801
InChi Key	VZXMZMJSGLFKQI-ABVWVHJUSA-N
Smiles	O=P(/C=C/CN1C[C@H]([C@](O)=O)NCC1)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D-CPP-ene

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	25	100

Preparing Stock Solutions for D-CPP-ene

The following data is based on the product molecular weight 250.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.00 mL	19.98 mL	39.97 mL
5 mM	0.80 mL	4.00 mL	7.99 mL
10 mM	0.40 mL	2.00 mL	4.00 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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Reconstitution Calculator

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References for D-CPP-ene

References are publications that support the biological activity of the product.

Potschka Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of DA and DA and serotonin metabolites in striatum of kindled and non-kindled rats. Eur.J.Pharmacol. 1999 PMID: 10422758
Aebischer Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta
Lowe D-CPP-ene (SDZ EAA 494), a potent and competitive N-MthD.-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci.Lett. 1990 PMID: 2166255