Davunetide

Name: Davunetide
Brand: Tocris Bioscience
SKU: 6779

Tocris Bioscience, part of Bio-Techne | Catalog # 6779

COA / SDS

Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo

Key Product Details

Description:	Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
Alternative Names:	AL-108,NAP (peptide),NAPVSIPQ
Purity:	≥95% (HPLC)
Molecular Weight:	824.93

View Full Technical Details for Davunetide

Technical Data
Citations

Biological Activity for Davunetide

Davunetide is a highly potent active component of activity-dependent neuroprotective protein (ADNP). Prevents β-amyloid aggregation. Reduces hyperphosphorylated tau levels and increases tau-microtubule interactions; neuroprotective at femtomolar concentrations in vitro. Exerts neuroprotective effects in schizophrenia models associated with microtubule-autophagy insufficiency in MAP6-deficient mice. Modulates HIFs and VEGF expression and suppresses retinal cell apoptosis in an in vivo diabetic retinopathy model.

Technical Data for Davunetide

M. Wt	824.93
Formula	C₃₆H₆₀N₁₀O₁₂
Single Letter Sequence	NAPVSIPQ
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	211439-12-2
PubChem ID	9832404
InChi Key	DWLTUUXCVGVRAV-XWRHUKJGSA-N
Smiles	O=C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Davunetide

Solubility

Soluble to 1mg/ml in water

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References for Davunetide

References are publications that support the biological activity of the product.

Ivashko-Pachima ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy. Mol Psychiatry 2017 PMID: 28115743
D'Amico NAP counteracts hyperglycemia/hypoxia induced retinal pigment epithelial barrier breakdown through modulation of HIFs and VEGF expression. J.Cell Physiol. 2018 PMID: 28436035
Melo Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease. Exp.Brain Res. 2017 PMID: 27866262
Sragovich ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease. Bioessays 2017 PMID: 28940660
Gozes Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze J.Pharmacol.Exp.Ther. 2000 PMID: 10869414
Bassan Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J.Neurochem. 1999 PMID: 10037502