DQP 1105

Name: DQP 1105
Brand: Tocris Bioscience
SKU: 4491

Tocris Bioscience, part of Bio-Techne | Catalog # 4491

Citations (19)

COA / SDS

GluN2C/GluN2D-selective NMDA antagonist

Key Product Details

Description:	GluN2C/GluN2D-selective NMDA antagonist
Chemical Name:	5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	558.42

View Full Technical Details for DQP 1105

Technical Data
Citations

Biological Activity for DQP 1105

DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC₅₀ values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for DQP 1105

DQP 1105 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DQP 1105

M. Wt	558.42
Formula	C₂₉H₂₄BrN₃O₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	380560-89-4
PubChem ID	2723792
InChi Key	JIQFFACVQXXHMY-YDALLXLXSA-N
Smiles	O=C2C(C4=NN(C(CCC(O)=O)=O)C(C5=CC=C(Br)C=C5)C4)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DQP 1105

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	55.84	100

Preparing Stock Solutions for DQP 1105

The following data is based on the product molecular weight 558.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.79 mL	8.95 mL	17.91 mL
5 mM	0.36 mL	1.79 mL	3.58 mL
10 mM	0.18 mL	0.90 mL	1.79 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for DQP 1105

References are publications that support the biological activity of the product.

Acker Mechanism for noncompetitive inhibition by novel GluN2C/D N-MthD.-aspartate receptor subunit-selective modulators. Mol.Pharmacol. 2011 PMID: 21807990