EN67, phenol

Name: EN67, phenol
Brand: Tocris Bioscience
SKU: 8003

Tocris Bioscience, part of Bio-Techne | Catalog # 8003

COA / SDS

UBE2D degrader building block

Key Product Details

Description:	UBE2D degrader building block
Chemical Name:	N-[[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl]-2-propenamide
Purity:	≥95% (HPLC)
Molecular Weight:	264.26

View Full Technical Details for EN67, phenol

Technical Data
Citations

Biological Activity for EN67, phenol

EN67, phenol is a UBE2D building block. It covalently binds with the allosteric C111 residue on E2 ubiquitin-conjugating enzymes UBE2D. It can be used in targeted protein degraders to degrade neo-substrate targets, including the target proteins BRD4 and androgen receptor, in a UBE2D-dependent manner.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for EN67, phenol

M. Wt	264.26
Formula	C₁₃H₁₃FN₂O₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	RCYKZLWHDJZATC-UHFFFAOYSA-N
Smiles	O=C(NCC1ON=C(C1)C2=CC(F)=C(O)C=C2)C=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for EN67, phenol

References are publications that support the biological activity of the product.

Forte Targeted Protein Degradation through E2 Recruitment. ACS Chem.Biol. 2023 PMID: 36940189