FR 180204

Name: FR 180204
Brand: Tocris Bioscience
SKU: 3706

Tocris Bioscience, part of Bio-Techne | Catalog # 3706

(2)

Citations (84)

COA / SDS

Selective ERK inhibitor

Key Product Details

Chemical Name:	5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
Purity:	≥98%
Molecular Weight:	327.34 kDa

View Full Technical Details for FR 180204

Technical Data
Citations / Reviews (2)

Biological Activity for FR 180204

FR 180204 is a selective ERK inhibitor (IC₅₀ values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC₅₀ = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC₅₀ = 3.1 μM).

Technical Data for FR 180204

M. Wt	327.34 kDa
Formula	C₁₈H₁₃N₇
Storage	Store at +4°C
Purity	≥98%
CAS Number	865362-74-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FR 180204

Solubility

Soluble Soluble to 100 mM in DMSO

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References for FR 180204

References are publications that support the biological activity of the product.

Carmon K, Gong X, Yi J, Thomas A, Liu Q RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A, 2014;111(13):E1221-9. 2014 PMID: 24639526
Fu W, Ruangkittisakul A, MacTavish D, Shi JY, Ballanyi K, Jhamandas JH Amyloid beta (Abeta) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J. Biol. Chem., 2012;287(22):18820-30. 2012 PMID: 22500019
Ohori et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem.Biophys.Res.Comm., 2005;336:357 PMID: 16139248
Perrett et al. Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C. J Biol Chem., 2013;19:288 PMID: 23754287