ERK Inhibitors Products
ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, ...
11 results for "ERK Inhibitors" in Products
11 results for "ERK Inhibitors" in Products
ERK Inhibitors Products
ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, ...
Potent and selective ERK2 inhibitor
Alternate Names: | VX 11e |
Chemical Name: | 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide |
Purity: | ≥98% (HPLC) |
Selective ERK inhibitor
Chemical Name: | 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine |
Purity: | ≥98% (HPLC) |
ERK5/BMK1 inhibitor; also BRD4 inhibitor
Chemical Name: | 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
Purity: | ≥98% (HPLC) |
ERK dimerization inhibitor
Chemical Name: | N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide |
Purity: | ≥98% (HPLC) |
Selective MEK5 and ERK5 inhibitor
Chemical Name: | (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide |
Purity: | ≥98% (HPLC) |
Potent and selective ERK5 inhibitor
Chemical Name: | 11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
Purity: | ≥98% (HPLC) |
Potent and selective ERK5 inhibitor
Chemical Name: | 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
Purity: | ≥98% (HPLC) |
Potent and selective KRASG12C inhibitor
Alternate Names: | Sotorasib |
Chemical Name: | (1R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one |
Purity: | ≥98% (HPLC) |
Potent and selective PERK inhibitor; orally bioavailable
Chemical Name: | 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride |
Purity: | ≥98% (HPLC) |
Naturally occuring flavonoid and antioxidant; neuroprotective
Chemical Name: | 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one |
Purity: | ≥97% (HPLC) |
Selective LPA2 receptor non-lipid agonist
Chemical Name: | 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid |
Purity: | ≥98% (HPLC) |