GLP-1 (9-36) amide

Name: GLP-1 (9-36) amide
Brand: Tocris Bioscience
SKU: 3266

Tocris Bioscience, part of Bio-Techne | Catalog # 3266

Citations (3)

COA / SDS

Metabolite of GLP-1-(7-36) (Cat. No. 2082)

Key Product Details

Description:	Metabolite of GLP-1-(7-36) (Cat. No. 2082)
Alternative Names:	Glucagon-like peptide 1 (9-36) amide
Purity:	≥95% (HPLC)
Molecular Weight:	3089.44

View Full Technical Details for GLP-1 (9-36) amide

Technical Data
Citations

Biological Activity for GLP-1 (9-36) amide

GLP-1 (9-36) amide is a N-terminal truncated metabolite of glucagon-like peptide GLP-1-(7-36) (Cat. No. 2082) formed by dipeptidyl peptidase-IV cleavage. Acts as an antagonist at the human GLP-1 receptor. Inhibits hepatic glucose production in vivo and is a weak insulinotropic agent.

Technical Data for GLP-1 (9-36) amide

M. Wt	3089.44
Formula	C₁₄₀H₂₁₄N₃₆O₄₃
Single Letter Sequence	EGTFTSDVSSYLEGQAAKEFIAWLVKGR (Modification: Arg-28 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	161748-29-4
PubChem ID	90488821
InChi Key	WPNGPBPCQMDAAD-WRFZDFFOSA-N
Smiles	[H]N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GLP-1 (9-36) amide

Solubility

Soluble to 2mg/ml in 0.025% acetic acid

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References for GLP-1 (9-36) amide

References are publications that support the biological activity of the product.

Elahi GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide is a glucoregulatory peptide. Obesity 2008 PMID: 18421270
Deacon Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J.Clin.Endocrinol.Met.
Knudsen and Pridal Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur.J.Pharmacol. 1996 PMID: 9016935