GSK 137647

Name: GSK 137647
Brand: Tocris Bioscience
SKU: 5257

Tocris Bioscience, part of Bio-Techne | Catalog # 5257

Citations (7)

COA / SDS

Potent and selective FFA4 (GPR120) agonist

Discontinued Product

5257 has been discontinued. View all Free Fatty Acid Receptor Agonists products.

Key Product Details

Chemical Name:	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Purity:	≥99%

View Full Technical Details for GSK 137647

Technical Data
Citations

Biological Activity for GSK 137647

GSK 137647 is a potent and selective FFA4 (GPR120) agonist (pEC₅₀ values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).

Technical Data for GSK 137647

Formula	C₁₆H₁₉NO₃S
Storage	Store at RT
Purity	≥99%
CAS Number	349085-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 137647

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for GSK 137647

References are publications that support the biological activity of the product.

H Sato, Y Taketomi, Y Miki, R Murase, K Yamamoto, M Murakami Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ?3 Polyunsaturated Fatty Acids in WAT Cell Rep, 2020;31(5):107579. 2020 PMID: 32375030
Sparks et al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett., 2014;24:3100 PMID: 24881566
Martin et al. Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J.Lipid Res., 2012;53:2256 PMID: 22904345

GSK 137647

Tocris Bioscience, part of Bio-Techne | Catalog # 5257

Key Product Details

Biological Activity for GSK 137647

Technical Data for GSK 137647

Solubility for GSK 137647

Dilution Calculator

Reconstitution Calculator

References for GSK 137647

Product Documents for GSK 137647

COA

Certificate of Analysis

SDS

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