GW 583340 dihydrochloride

Name: GW 583340 dihydrochloride
Brand: Tocris Bioscience
SKU: 2239

Tocris Bioscience, part of Bio-Techne | Catalog # 2239

Citations (1)

COA / SDS

Potent dual EGFR/ErbB2 inhibitor; orally active

Key Product Details

Chemical Name:	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
Purity:	≥97%
Molecular Weight:	671.03 kDa

View Full Technical Details for GW 583340 dihydrochloride

Technical Data
Citations

Biological Activity for GW 583340 dihydrochloride

GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC₅₀ values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC₅₀ values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.

Technical Data for GW 583340 dihydrochloride

M. Wt	671.03 kDa
Formula	C₂₈H₂₅ClFN₅O₃S₂.2HCl
Storage	Desiccate at +4°C
Purity	≥97%
CAS Number	1173023-85-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 583340 dihydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO with gentle warming

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References for GW 583340 dihydrochloride

References are publications that support the biological activity of the product.

Gaul et al. Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg.Med.Chem.Lett., 2003;13:637 PMID: 12639547