HX 531

Name: HX 531
Brand: Tocris Bioscience
SKU: 3912
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3912

(1)

Citations (47)

COA / SDS

Potent RXR antagonist

Key Product Details

Description:	Potent RXR antagonist
Chemical Name:	4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	483.56

View Full Technical Details for HX 531

Technical Data
Citations / Reviews (1)

Biological Activity for HX 531

HX 531 is a potent RXR antagonist (IC₅₀ = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts.

Technical Data for HX 531

M. Wt	483.56
Formula	C₂₉H₂₉N₃O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	188844-34-0
PubChem ID	11755040
InChi Key	SXKPGYKPQPYJER-UHFFFAOYSA-N
Smiles	CC1(C)C2=C(C=C(N(C)C(C=CC([N+]([O-])=O)=C5)=C5N=C3C4=CC=C(C(O)=O)C=C4)C3=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HX 531

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.67	20

Preparing Stock Solutions for HX 531

The following data is based on the product molecular weight 483.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.34 mL	51.70 mL	103.40 mL
1 mM	2.07 mL	10.34 mL	20.68 mL
2 mM	1.03 mL	5.17 mL	10.34 mL
10 mM	0.21 mL	1.03 mL	2.07 mL

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References for HX 531

References are publications that support the biological activity of the product.

Nie Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 2017 PMID: 28099842
Alique Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration. Br.J.Pharmacol. 2006 PMID: 16847438
Suzuki Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells. Biol.Pharm.Bull. 2009 PMID: 19571381
Ebisawa Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem.Pharm.Bull. 1999 PMID: 10748721