Hydroxy Dynasore

Name: Hydroxy Dynasore
Brand: Tocris Bioscience
SKU: 5364

Tocris Bioscience, part of Bio-Techne | Catalog # 5364

Citations (4)

COA / SDS

Dynamin inhibitor; analog of dynasore (Cat. No. 2897)

Key Product Details

Description:	Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
Alternative Names:	Dyngo 4a
Chemical Name:	3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	338.31

View Full Technical Details for Hydroxy Dynasore

Technical Data
Citations

Biological Activity for Hydroxy Dynasore

Hydroxy Dynasore is a dynamin inhibitor (IC₅₀ values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).

Technical Data for Hydroxy Dynasore

M. Wt	338.31
Formula	C₁₈H₁₄N₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1256493-34-1
PubChem ID	72193863
InChi Key	ATUDAZGVGGVSOP-XFXZXTDPSA-N
Smiles	OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Hydroxy Dynasore

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.23	100

Preparing Stock Solutions for Hydroxy Dynasore

The following data is based on the product molecular weight 338.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.56 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for Hydroxy Dynasore

References are publications that support the biological activity of the product.

McCluskey Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 2013 PMID: 24025110
Harper Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J.Biol.Chem. 2011 PMID: 21832053