IBG3
Tocris Bioscience, part of Bio-Techne | Catalog # 8129
Potent molecular glue Degrader of BET proteins BRD4 and BRD2
Key Product Details
| Description: | Potent molecular glue Degrader of BET proteins BRD4 and BRD2 |
| Chemical Name: | tert-Butyl 2-((S)-4-(4-((4'-((S)-6-(2-(tert-butoxy)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-[1,1'-biphenyl]-4-carboxamido)methyl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
| Molecular Weight: | 976.23 |
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Published vs Bio-Techne batch comparison for IBG3. Endogenous HiBiT-BRD4 HEK293 cells were plated at a density of 20,000 cell per well in 100 µL of DMEM (10% FBS) in a white-walled 96 well plate and left overnight to adhere at 37 ºC, 5% CO2. Cells were incubated in 50 µL of 10 nM-0.1 pM of IBG3 or vehicle control (DMSO) in Optimem (10% FBS) and left for 4 hours. Cells were then treated with HiBIT Lytic assay reagent– and plates were then read on a BMG Pherastar plate reader for luminescence detection. Data kindly provided by the Ciulli laboratory, University of Dundee. |
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