IBG3

Name: IBG3
Brand: Tocris Bioscience
SKU: 8129

Tocris Bioscience, part of Bio-Techne | Catalog # 8129

COA / SDS

Potent molecular glue Degrader of BRD4 and BRD2 bromodomains

Key Product Details

Description:	Potent molecular glue Degrader of BRD4 and BRD2 bromodomains
Chemical Name:	tert-Butyl 2-((S)-4-(4-((4'-((S)-6-(2-(tert-butoxy)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-[1,1'-biphenyl]-4-carboxamido)methyl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Molecular Weight:	976.23

View Full Technical Details for IBG3

Technical Data
Citations

Biological Activity for IBG3

IBG3 is a very potent JQ1-containing molecular glue Degrader of BET bromodomains BRD4 and BRD2 (DC₅₀ values are 6.7 pM and 8.6 pM respectively). Induces proximity between BRD4 and DCAF16 to form a ternary complex (EC₅₀ = 32 nM).

Technical Data for IBG3

M. Wt	976.23
Formula	C₅₄H₅₇N₉O₅S₂
Storage	Store at -20°C
PubChem ID	171037958
InChi Key	MRIUQCAXSFYTQZ-YATWDLPUSA-N
Smiles	CC1=C(SC2=C1C(C3=CC=C(C=C3)C4=CC=C(C=C4)C(NCC5=CC=C(C6=N[C@H](C7=NN=C(N7C8=C6C(C)=C(S8)C)C)CC(OC(C)(C)C)=O)C=C5)=O)=N[C@H](C9=NN=C(N92)C)CC(OC(C)(C)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IBG3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	97.62	100

Preparing Stock Solutions for IBG3

The following data is based on the product molecular weight 976.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.02 mL	5.12 mL	10.24 mL
5 mM	0.20 mL	1.02 mL	2.05 mL
10 mM	0.10 mL	0.51 mL	1.02 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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References for IBG3

References are publications that support the biological activity of the product.

Hsia Targeted protein degradation via intramolecular bivalent glues. Nature 2024 PMID: 38383787