INCB 3284 dimesylate

Name: INCB 3284 dimesylate
Brand: Tocris Bioscience
SKU: 4306

Tocris Bioscience, part of Bio-Techne | Catalog # 4306

Citations (1)

COA / SDS

Selective CCR2 antagonist

Key Product Details

Description:	Selective CCR2 antagonist
Chemical Name:	N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	712.76

View Full Technical Details for INCB 3284 dimesylate

Technical Data
Citations

Biological Activity for INCB 3284 dimesylate

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC₅₀ values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC₅₀ = 84μ M). Orally bioavailable.

Compound Libraries for INCB 3284 dimesylate

INCB 3284 dimesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for INCB 3284 dimesylate

M. Wt	712.76
Formula	C₂₆H₃₁F₃N₄O₄.2CH₄O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	887401-93-6
PubChem ID	11679268
InChi Key	PNPNUHKICDECDH-SEBNIYPMSA-N
Smiles	O=C(NCC(N[C@@H]2CCN([C@H]3CC[C@](C4=CC=C(OC)N=C4)(O)CC3)C2)=O)C1=CC(C(F)(F)F)=CC=C1.CS(=O)(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INCB 3284 dimesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	71.28	100
	DMSO	71.28	100

Preparing Stock Solutions for INCB 3284 dimesylate

The following data is based on the product molecular weight 712.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.40 mL	7.01 mL	14.03 mL
5 mM	0.28 mL	1.40 mL	2.81 mL
10 mM	0.14 mL	0.70 mL	1.40 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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References for INCB 3284 dimesylate

References are publications that support the biological activity of the product.

Xue Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist. ACS.Med.Chem.Lett. 2011 PMID: 24900329