Iressa

Tocris Bioscience, part of Bio-Techne | Catalog # 3000

COA / SDS

Orally active, selective EGFR inhibitor

Key Product Details

Description:	Orally active, selective EGFR inhibitor
Alternative Names:	Gefitinib,ZD 1839
Chemical Name:	N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	446.9

View Full Technical Details for Iressa

Technical Data
Citations

Biological Activity for Iressa

Iressa is an orally active, selective inhibitor of EGFR tyrosine kinase (IC₅₀ = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. Also inhibits growth of brain metastases in mouse model of non-small cell lung cancer.

View information regarding the usage of Iressa for non-clinical studies.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Compound Libraries for Iressa

Iressa is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Iressa

M. Wt	446.9
Formula	C₂₂H₂₄ClFN₄O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	184475-35-2
PubChem ID	123631
InChi Key	XGALLCVXEZPNRQ-UHFFFAOYSA-N
Smiles	FC(C=C3)=C(Cl)C=C3NC2=NC=NC1=CC(OC)=C(OCCCN4CCOCC4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Iressa

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.69	100
	ethanol	4.47	10

Preparing Stock Solutions for Iressa

The following data is based on the product molecular weight 446.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.19 mL	22.38 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for Iressa

References are publications that support the biological activity of the product.

Tan Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: A direct comparative analysis of icotinib, gefitinib, and erlo. in a nude mouse model. Oncotarget. 2017 PMID: 29228726
Baselga ZD1839 ('Iressa'), as an anticancer agent. Drugs 2000 PMID: 11129170
McKillop Tumor penetration of gefi. (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor. Mol.Cancer Ther. 2005 PMID: 15827338
Ciardiello Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin.Cancer Res. 2000 PMID: 10815932