iso-PPADS tetrasodium salt

Name: iso -PPADS tetrasodium salt
Brand: Tocris Bioscience
SKU: 0683
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0683

(1)

Citations (6)

COA / SDS

Non-selective P2X antagonist

Key Product Details

Description:	Non-selective P2X antagonist
Chemical Name:	Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Molecular Weight:	599.3

View Full Technical Details for iso-PPADS tetrasodium salt

Technical Data
Citations / Reviews (1)

Biological Activity for iso-PPADS tetrasodium salt

iso-PPADS tetrasodium salt is a P2X-purinoceptor antagonist (pK_i = 6.5) with similar activity to PPADS.

2'4'-isomer also available.

Technical Data for iso-PPADS tetrasodium salt

M. Wt	599.3
Formula	C₁₄H₁₀N₃Na₄O₁₂PS₂
Storage	Desiccate at -20°C
CAS Number	207572-67-6
PubChem ID	5132514
InChi Key	LOTSPVPQHAUHCE-UHFFFAOYSA-N
Smiles	[Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(\N=N\C2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for iso-PPADS tetrasodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	59.93	100

Preparing Stock Solutions for iso-PPADS tetrasodium salt

The following data is based on the product molecular weight 599.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.67 mL	8.34 mL	16.69 mL
5 mM	0.33 mL	1.67 mL	3.34 mL
10 mM	0.17 mL	0.83 mL	1.67 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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Reconstitution Calculator

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References for iso-PPADS tetrasodium salt

References are publications that support the biological activity of the product.

Khakh Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 1994 PMID: 7843268
Trezise The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 1994 PMID: 8032652
Connolly Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 1995 PMID: 7735699