JNJ 28871063 hydrochloride

Name: JNJ 28871063 hydrochloride
Brand: Tocris Bioscience
SKU: 3352

Tocris Bioscience, part of Bio-Techne | Catalog # 3352

Citations (1)

COA / SDS

Potent ErbB receptor family inhibitor

Key Product Details

Description:	Potent ErbB receptor family inhibitor
Chemical Name:	5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	519.42

View Full Technical Details for JNJ 28871063 hydrochloride

Technical Data
Citations

Biological Activity for JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC₅₀ values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC₅₀ = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.

Compound Libraries for JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 28871063 hydrochloride

M. Wt	519.42
Formula	C₂₄H₂₇ClN₆O₃.HCl
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	944342-90-9
PubChem ID	17747413
InChi Key	ZXKZRKQMKNRZNN-GZPZNDDGSA-N
Smiles	NC1=C(/C=N/OCCN2CCOCC2)C(NC3=CC(Cl)=C(OCC4=CC=CC=C4)C=C3)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 28871063 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.97	50

Preparing Stock Solutions for JNJ 28871063 hydrochloride

The following data is based on the product molecular weight 519.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.85 mL	19.25 mL	38.50 mL
2.5 mM	0.77 mL	3.85 mL	7.70 mL
5 mM	0.39 mL	1.93 mL	3.85 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

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References for JNJ 28871063 hydrochloride

References are publications that support the biological activity of the product.

Emanuel Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 2008 PMID: 17975007
Guessous Signaling pathways in medulloblastoma. J.Cell.Phys. 2008 PMID: 18651559
Contessa and Hamstra Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 2008 PMID: 17981994