JP-2-196 alkyne

Name: JP-2-196 alkyne
Brand: Tocris Bioscience
SKU: 8047

Tocris Bioscience, part of Bio-Techne | Catalog # 8047

COA / SDS

RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).

Key Product Details

Description:	RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).
Chemical Name:	1-(4-Methoxyphenyl)-4-[4-(2-propyn-1-yl)-1-piperazinyl]-2-butene-1,4-dione
Purity:	≥95% (HPLC)
Molecular Weight:	312.37

View Full Technical Details for JP-2-196 alkyne

Technical Data
Citations

Biological Activity for JP-2-196 alkyne

JP-2-196 alkyne is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM1. By facilitating E3 ligase recruitment, JP-2-196 alkyne induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders. JP-2-196 alkyne is an alkyne functionalized version of JP-2-196 (Cat. No. 8046).

Technical Data for JP-2-196 alkyne

M. Wt	312.37
Formula	C₁₈H₂₀N₂O₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2901113-25-3
PubChem ID	167740300
InChi Key	COPXSSDNGLPYDY-CMDGGOBGSA-N
Smiles	O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCN(CC2)CC#C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JP-2-196 alkyne

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.24	100

Preparing Stock Solutions for JP-2-196 alkyne

The following data is based on the product molecular weight 312.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.01 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for JP-2-196 alkyne

References are publications that support the biological activity of the product.

Toriki Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 2023 PMID: 37252349